In the early ’90s, we identified, quantified and published widely on the importance of the pattern and thickness of the uterine lining (endometrium) in determining outcome following in vitro fertilization (IVF). Women in whom the thickness of the endometrium had an abnormal ultrasound pattern and measured less than 9mm around the time of egg retrieval … Read more

A new process which allows doctors to identify the embryos most likely to make a baby through IVF.

Staggered IVF is a new approach to IVF. It involves the use of CGH to identify chromosomally normal (“competent”) embryos/blastocysts for selective transfer, thereby markedly improving the efficiency of the entire process. It addresses three important issues: First, it significantly increases the success rate per embryo transferred and thereby allows fewer embryos to be transferred … Read more

Most methods of determining which embryo to transfer to the uterus during In Vitro Fertilization rely on a visual assessment under the microscope.  The prettiest embryo wins.  Unfortunately, this approach ignores the most common cause of IVF failure – chromosomal abnormalities.  Doctors can’t tell by simply looking at an embryo whether it is chromosomally “competent.”  … Read more

The introduction of Vitrification combined with CGH technology has opened up new possibilities for IVF treatment and fertility preservation. One dilemma that women face when considering IVF at a later age is the fact that they generally have fewer eggs available, and of those, a higher percentage are chromosomally abnormal. A new option that has … Read more

For more than a quarter century, medical scientists have attempted to defy the biological clock by freezing a woman’s eggs to preserve her fertility. Until recently, almost all such efforts have yielded very poor results. This is why, since the birth of the 1st “frozen egg baby” in the mid 1980’s, fewer than 1500 such … Read more

INTRALIPID 20% – FINALLY AN EFFECTIVE, SAFE AND LOW COST ALTERNATIVE TO IVIG THERAPY SIRM physicians have long advocated aggressive treatment of immunologic implantation dysfunction in women undergoing IVF. In cases where there has been Natural Killer Cell activation (Nka) (as evidenced by an abnormal K562 target cell test) we have championed the use of … Read more

THE EVOLUTION OF CGH EGG AND EMBRYO TESTING AT SIRM Geoffrey Sher MD Three problems have restricted the growth of IVF in the U.S: 1) Cost of service and lack of insurance reimbursement, 2) Ignorance of the fact that IVF is far more efficacious than other infertility treatment and, 3) OB-Gyn’s and/or Reproductive Endocrinologists (RE’s) that … Read more

Sher Institute Founder, Geoffrey Sher has long been a pioneer in the field and has, along with SIRM colleagues, introduced: 1982: First to recommend the exclusive use of gonadotropins to stimulate follicular development for IVF 1983: First to introduce Intrauterine Insemination (IUI) of washed sperm for treating certain forms of infertility. 1989: First to report … Read more