Fertility Information
Infertility can be an overwhelming experience. Our aim is to give you the information you need to make informed decisions about your fertility. We have provided a wealth of information on this site in order to help you gain an understanding of the many facets of fertility and reproductive medicine. Whether you are just getting started and are interested in the basics, or you are a seasoned veteran looking for in-depth information on a particular condition, treatment, or technology, this site has the info you need to inform and empower you. Select an option below to get started.
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Featured Article
Complete DQ alpha Match *Without* Natural Killer Cell Activation
Background: “Joanne”, a 36-year-old lady with normal ovarian reserve, had undergone three IVF procedures in a prior relationship. The indication had been "bilateral tubal occlusion." The reason why all three IVF attempts had failed was unknown. Now, since her new husband, “Brett” had severe male factor infertility, IVF with intracytoplasmic sperm injection (ICSI) became their only choice. Because of Joanne’s prior unexplained IVF failures, I decided to do both autoimmune and alloimmune testing. The results showed that both Joanne and Brett had identical DQ alpha genotypes (a “complete match”). However, Joanne tested negative for activated uterine natural killer cells (NKa) as measured by the K-562 target cell test. Treatment: Joanne was prescribed a birth control pill (BCP) which she took for 15 days and then overlapped it with Lupron for 2 days. The BCP was then stopped. Menstruation ensued after 5 days of Lupron, at which time the Lupron dosage was reduced, ... Read more
Recent Fertility Post
Endometriosis is one of the most widespread conditions affecting women’s fertility. Of the approximately 6 million women in the US with some degree of endometriosis, more than a million of those will have trouble conceiving as a result. Join me for a live webinar where I’ll address questions including: How/why does endometriosis affect fertility? Does … Read more
I’m happy to announce that after several rounds of major revisions, re-writes, and additions, the 4th edition of my book “In Vitro Fertilization: The ART of Making Babies” has been released. It is a comprehensive guide to IVF, addressing causes of infertility, diagnosis and testing, and treatment options, with a special emphasis on on the … Read more
Background: Mary, 30 years of age and married to a fertile male partner, presented to me about four years ago with primary amenorrhea (i.e. she had never menstruated) and wanting to have a baby. She was born with a condition called Rokitansky syndrome, where the uterus fails to develop. Absent of regular menstruation, Mary had … Read more
My thanks to SIRM’s Executive Director of Embryology, Levent Keskintepe, PhD for writing this week’s post. Dr. Keskintepe is truly a leader in the field of embryology and has had a vital role in bringing CGH technology as we know it to the forefront in IVF. Background Information: About a decade ago, we at SIRM … Read more
In the United States, the richest and most technically advanced nation on earth, millions of couples remain involuntarily childless. A conservative estimate places the number of U.S. couples that grapple with infertility annually at 4 million, yet less than 20 percent of those couples will undergo some form of definitive treatment. The high cost of … Read more
RL, a 31-year-old woman, presented with a 7 year history of inability to conceive, in spite of 2 prior fresh and 1 frozen IVF attempts, where a total of six good quality blastocysts had been transferred to her uterus. Her husband PL, had normal sperm and had initiated 2 pregnancies in a prior relationship. RL … Read more
While many IVF pregnancies will progress normally and without any increased risk to mother or baby, there is little doubt that some women who conceive in this manner as well as their babies are indeed at increased risk. Why is it that women who conceive following IVF should be regarded as being “high risk” and … Read more
The following is a case study of a recent patient that came to me for treatment. CJ, a 34 year old, and her husband RJ (age 35) presented to me with a six-year history of infertility. Based on semen analysis, RJ, who had initiated two pregnancies in a prior relationship, was found to be perfectly … Read more
Please refer to last week’s blog post, where Karmann tells in her own words her struggles with recurrent miscarriage – nine miscarriages to be exact – and her long journey of heartbreak, disappointment, and finally – hope. In this post, I offer my perspective on her case from a medical standpoint. ———————- When … Read more
In observation of National Infertility Awareness Week (NIAW), I wanted to share the touching story of a couple that I first met last year – after they had already experienced 8 years of heartbreak and frustration. Their story is representative of what so many couples go through in their infertility journey. Rather than tell … Read more
This week, with the passing of Robert Edwards, has been a particularly sad one for the entire field of Reproductive Medicine. Bob Edwards and Patrick Steptoe (who passed a few years ago) pioneered human IVF and together were responsible for the birth of Louise Brown, the world’s first IVF baby, some 35 years ago. He … Read more
Background: About two years ago, I received a call from a gentleman that I will call “John”. John was a movie producer who stated that he and his partner “Brian” had been in a monogamous same-sex relationship for 7 years and each wanted to sire a child. At the initial consultation, John explained that he … Read more
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